Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
casr_human | 25 | N-term | R => Ter | stop gained | 1.649e-05 | 2 | 121280 | 0 | None | None | ||
casr_human | 101 | N-term | C => Ter | stop gained | 8.237e-06 | 1 | 121410 | 0 | None | None | ||
casr_human | 159 | N-term | L => SerfsTer98 | frameshift | 8.282e-06 | 1 | 120746 | 0 | None | None | ||
casr_human | 389 | N-term | T => GlnfsTer21 | frameshift | 8.237e-06 | 1 | 121402 | 0 | None | None | ||
casr_human | 545 | N-term | D => SerfsTer92 | frameshift | 8.237e-06 | 1 | 121410 | 0 | None | None | ||
casr_human | 658 | 2.46x46 | TM2 | L => Ter | stop gained | 8.244e-06 | 1 | 121294 | 0 | None | None | |
casr_human | 993 | C-term | T => ArgfsTer25 | frameshift | 8.242e-06 | 1 | 121328 | 0 | None | None | ||
casr_human | 11 | N-term | L => S | missense | 8.243e-06 | 1 | 121314 | 0 | nan | 0.402 | ||
casr_human | 14 | N-term | T => A | missense | 1.648e-05 | 2 | 121326 | 0 | nan | 0.001 | ||
casr_human | 16 | N-term | H => Y | missense | 8.242e-06 | 1 | 121328 | 0 | 1.0 | 0.001 | ||
casr_human | 18 | N-term | S => F | missense | 1.648e-05 | 2 | 121334 | 0 | nan | 0.672 | ||
casr_human | 25 | N-term | R => Q | missense | 1.649e-05 | 2 | 121280 | 0 | 0.11 | 0.983 | ||
casr_human | 31 | N-term | D => E | missense | 8.251e-06 | 1 | 121200 | 0 | 0.06 | 0.972 | ||
casr_human | 33 | N-term | I => S | missense | 3.301e-05 | 4 | 121190 | 0 | 0.02 | 0.217 | ||
casr_human | 45 | N-term | A => G | missense | 8.267e-06 | 1 | 120968 | 0 | 0.17 | 0.228 | ||
casr_human | 45 | N-term | A => E | missense | 8.267e-06 | 1 | 120968 | 0 | 0.51 | 0.041 | ||
casr_human | 60 | N-term | C => Y | missense | 8.304e-06 | 1 | 120428 | 0 | 0.0 | 1.0 | ||
casr_human | 69 | N-term | R => H | missense | 1.648e-05 | 2 | 121364 | 0 | 0.0 | 1.0 | ||
casr_human | 74 | N-term | M => L | missense | 8.239e-06 | 1 | 121378 | 0 | 0.01 | 0.996 | ||
casr_human | 78 | N-term | I => V | missense | 1.648e-05 | 2 | 121388 | 0 | 0.09 | 0.605 | ||
casr_human | 89 | N-term | P => R | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 1.0 | ||
casr_human | 90 | N-term | N => T | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.993 | PTM (N-linked Glycosylation) | |
casr_human | 92 | N-term | T => M | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 0.991 | ||
casr_human | 103 | N-term | T => I | missense | 2.471e-05 | 3 | 121410 | 0 | 0.03 | 0.997 | ||
casr_human | 122 | N-term | S => Y | missense | 8.238e-06 | 1 | 121388 | 0 | 0.05 | 0.995 | ||
casr_human | 140 | N-term | A => V | missense | 8.244e-06 | 1 | 121304 | 0 | 0.09 | 0.99 | ||
casr_human | 143 | N-term | G => R | missense | 8.247e-06 | 1 | 121258 | 0 | 0.0 | 1.0 | ||
casr_human | 144 | N-term | A => T | missense | 8.247e-06 | 1 | 121256 | 0 | 0.56 | 0.993 | ||
casr_human | 149 | N-term | V => I | missense | 8.257e-06 | 1 | 121112 | 0 | 0.48 | 0.004 | ||
casr_human | 152 | N-term | A => V | missense | 1.653e-05 | 2 | 120994 | 0 | 0.14 | 0.644 | ||
casr_human | 159 | N-term | L => V | missense | 8.283e-06 | 1 | 120736 | 0 | 0.53 | 0.487 | ||
casr_human | 175 | N-term | S => R | missense | 8.251e-06 | 1 | 121196 | 0 | 0.0 | 1.0 | ||
casr_human | 176 | N-term | N => K | missense | 1.65e-05 | 2 | 121210 | 0 | 0.02 | 0.99 | ||
casr_human | 187 | N-term | I => T | missense | 8.245e-06 | 1 | 121282 | 0 | 0.0 | 0.932 | ||
casr_human | 189 | N-term | N => S | missense | 8.244e-06 | 1 | 121300 | 0 | 1.0 | 0.057 | ||
casr_human | 191 | N-term | E => G | missense | 8.244e-06 | 1 | 121302 | 0 | 0.3 | 0.951 | ||
casr_human | 205 | N-term | R => C | missense | 8.245e-06 | 1 | 121282 | 0 | 0.0 | 0.873 | ||
casr_human | 205 | N-term | R => H | missense | 1.649e-05 | 2 | 121282 | 0 | 0.03 | 0.018 | ||
casr_human | 216 | N-term | D => N | missense | 8.245e-06 | 1 | 121290 | 0 | 0.25 | 1.0 | ||
casr_human | 217 | N-term | D => N | missense | 1.649e-05 | 2 | 121284 | 0 | 0.02 | 0.099 | ||
casr_human | 227 | N-term | R => Q | missense | 8.244e-06 | 1 | 121300 | 0 | 0.73 | 0.756 | ||
casr_human | 235 | N-term | I => M | missense | 1.648e-05 | 2 | 121344 | 0 | 0.04 | 0.997 | ||
casr_human | 238 | N-term | D => N | missense | 2.472e-05 | 3 | 121348 | 0 | 0.89 | 0.01 | ||
casr_human | 240 | N-term | S => T | missense | 1.648e-05 | 2 | 121364 | 0 | 0.12 | 0.111 | ||
casr_human | 247 | N-term | S => F | missense | 3.295e-05 | 4 | 121394 | 0 | 0.7 | 0.006 | ||
casr_human | 250 | N-term | E => K | missense | 0.001837 | 223 | 121396 | 0 | 0.21 | 0.006 | ||
casr_human | 251 | N-term | E => G | missense | 1.648e-05 | 2 | 121394 | 0 | 0.02 | 0.16 | ||
casr_human | 253 | N-term | Q => K | missense | 9.061e-05 | 11 | 121394 | 0 | 0.94 | 0.002 | ||
casr_human | 253 | N-term | Q => L | missense | 8.238e-06 | 1 | 121394 | 0 | 0.41 | 0.068 | ||
casr_human | 257 | N-term | E => G | missense | 8.238e-06 | 1 | 121388 | 0 | 0.15 | 0.01 | ||
casr_human | 258 | N-term | V => A | missense | 8.238e-06 | 1 | 121384 | 0 | 0.11 | 0.046 | ||
casr_human | 260 | N-term | Q => R | missense | 0.0001236 | 15 | 121382 | 0 | 0.21 | 0.186 | ||
casr_human | 263 | N-term | T => M | missense | 8.239e-06 | 1 | 121374 | 0 | 0.0 | 0.956 | ||
casr_human | 263 | N-term | T => K | missense | 8.239e-06 | 1 | 121374 | 0 | 0.03 | 0.674 | ||
casr_human | 272 | N-term | S => G | missense | 8.243e-06 | 1 | 121320 | 0 | 0.25 | 0.057 | ||
casr_human | 279 | N-term | L => V | missense | 8.247e-06 | 1 | 121256 | 0 | 0.05 | 0.725 | ||
casr_human | 282 | N-term | E => G | missense | 1.65e-05 | 2 | 121238 | 0 | 0.0 | 0.989 | ||
casr_human | 283 | N-term | I => T | missense | 0.000132 | 16 | 121230 | 0 | 0.0 | 0.801 | ||
casr_human | 285 | N-term | R => P | missense | 8.25e-06 | 1 | 121206 | 0 | 0.05 | 0.468 | ||
casr_human | 289 | N-term | T => M | missense | 8.259e-06 | 1 | 121076 | 0 | 0.0 | 1.0 | ||
casr_human | 291 | N-term | K => N | missense | 8.269e-06 | 1 | 120930 | 0 | 0.31 | 0.366 | ||
casr_human | 305 | N-term | I => V | missense | 8.261e-06 | 1 | 121058 | 0 | 0.14 | 0.217 | ||
casr_human | 307 | N-term | M => I | missense | 2.479e-05 | 3 | 121040 | 0 | 0.11 | 0.173 | ||
casr_human | 308 | N-term | P => L | missense | 8.262e-06 | 1 | 121042 | 0 | 0.02 | 0.869 | ||
casr_human | 316 | N-term | G => S | missense | 8.265e-06 | 1 | 120996 | 0 | 0.03 | 0.52 | ||
casr_human | 318 | N-term | I => V | missense | 8.263e-06 | 1 | 121016 | 0 | 0.09 | 0.683 | ||
casr_human | 324 | N-term | A => P | missense | 8.264e-06 | 1 | 121012 | 0 | 0.09 | 0.032 | ||
casr_human | 325 | N-term | G => R | missense | 8.264e-06 | 1 | 121014 | 0 | 0.0 | 1.0 | ||
casr_human | 331 | N-term | R => Q | missense | 8.264e-06 | 1 | 121014 | 0 | 0.12 | 0.805 | ||
casr_human | 336 | N-term | K => N | missense | 1.652e-05 | 2 | 121076 | 0 | 0.35 | 0.015 | PTM (Acetylation) | |
casr_human | 336 | N-term | K => N | missense | 8.259e-06 | 1 | 121076 | 0 | 0.35 | 0.015 | PTM (Acetylation) | |
casr_human | 337 | N-term | V => F | missense | 8.259e-06 | 1 | 121080 | 0 | 0.0 | 0.993 | ||
casr_human | 338 | N-term | H => R | missense | 8.258e-06 | 1 | 121088 | 0 | 0.46 | 0.068 | ||
casr_human | 340 | N-term | R => K | missense | 1.652e-05 | 2 | 121096 | 0 | 0.74 | 0.0 | ||
casr_human | 343 | N-term | V => I | missense | 1.651e-05 | 2 | 121146 | 0 | 0.18 | 0.002 | ||
casr_human | 343 | N-term | V => A | missense | 8.254e-06 | 1 | 121148 | 0 | 0.34 | 0.001 | ||
casr_human | 345 | N-term | N => D | missense | 8.253e-06 | 1 | 121166 | 0 | 0.11 | 0.133 | ||
casr_human | 360 | N-term | L => F | missense | 8.242e-06 | 1 | 121328 | 0 | 0.6 | 0.376 | ||
casr_human | 363 | N-term | G => S | missense | 8.241e-06 | 1 | 121344 | 0 | 0.41 | 0.002 | ||
casr_human | 364 | N-term | A => E | missense | 1.648e-05 | 2 | 121350 | 0 | 0.76 | 0.049 | ||
casr_human | 366 | N-term | G => E | missense | 8.24e-06 | 1 | 121358 | 0 | 0.12 | 0.124 | ||
casr_human | 367 | N-term | P => S | missense | 1.648e-05 | 2 | 121362 | 0 | 0.47 | 0.003 | ||
casr_human | 371 | N-term | D => N | missense | 8.239e-06 | 1 | 121368 | 0 | 0.29 | 0.086 | ||
casr_human | 372 | N-term | T => A | missense | 8.239e-06 | 1 | 121370 | 0 | 0.43 | 0.001 | ||
casr_human | 375 | N-term | R => K | missense | 2.472e-05 | 3 | 121366 | 0 | 0.64 | 0.001 | ||
casr_human | 382 | N-term | D => N | missense | 3.295e-05 | 4 | 121390 | 0 | 0.82 | 0.001 | ||
casr_human | 387 | N-term | S => G | missense | 8.237e-06 | 1 | 121402 | 0 | 0.37 | 0.003 | ||
casr_human | 388 | N-term | S => W | missense | 1.647e-05 | 2 | 121400 | 0 | 0.0 | 0.868 | ||
casr_human | 390 | N-term | A => G | missense | 8.237e-06 | 1 | 121400 | 0 | 0.27 | 0.111 | ||
casr_human | 398 | N-term | D => N | missense | 0.000486 | 59 | 121406 | 0 | 0.39 | 0.007 | ||
casr_human | 398 | N-term | D => G | missense | 3.295e-05 | 4 | 121406 | 0 | 0.24 | 0.049 | ||
casr_human | 400 | N-term | N => I | missense | 3.295e-05 | 4 | 121404 | 0 | 0.01 | 0.951 | ||
casr_human | 402 | N-term | S => R | missense | 8.237e-06 | 1 | 121404 | 0 | 0.54 | 0.211 | ||
casr_human | 403 | N-term | S => C | missense | 8.237e-06 | 1 | 121404 | 0 | 0.01 | 0.937 | ||
casr_human | 429 | N-term | H => Y | missense | 0.001797 | 218 | 121306 | 2 | 0.15 | 0.022 | ||
casr_human | 429 | N-term | H => Q | missense | 2.473e-05 | 3 | 121302 | 0 | 0.04 | 0.12 | ||
casr_human | 433 | N-term | D => H | missense | 0.000198 | 24 | 121224 | 0 | 0.01 | 0.95 | ||
casr_human | 433 | N-term | D => Y | missense | 8.249e-06 | 1 | 121224 | 0 | 0.0 | 0.975 | ||
casr_human | 445 | N-term | T => A | missense | 0.0238 | 2871 | 120628 | 377 | 0.73 | 0.017 | ||
casr_human | 447 | N-term | G => D | missense | 8.299e-06 | 1 | 120494 | 0 | 0.24 | 0.793 | ||
casr_human | 451 | N-term | D => N | missense | 8.313e-06 | 1 | 120298 | 0 | 0.45 | 0.409 | ||
casr_human | 452 | N-term | I => V | missense | 8.317e-06 | 1 | 120238 | 0 | 0.09 | 0.78 | ||
casr_human | 460 | N-term | V => I | missense | 8.247e-06 | 1 | 121262 | 0 | 0.06 | 0.519 | ||
casr_human | 463 | N-term | H => Q | missense | 4.121e-05 | 5 | 121326 | 0 | 0.12 | 0.114 | ||
casr_human | 464 | N-term | L => V | missense | 8.242e-06 | 1 | 121330 | 0 | 0.02 | 0.869 | ||
casr_human | 465 | N-term | R => W | missense | 1.648e-05 | 2 | 121338 | 0 | 0.0 | 0.939 | ||
casr_human | 466 | N-term | H => Y | missense | 8.24e-06 | 1 | 121352 | 0 | 0.04 | 0.934 | ||
casr_human | 466 | N-term | H => Q | missense | 8.24e-06 | 1 | 121360 | 0 | 0.32 | 0.905 | ||
casr_human | 469 | N-term | F => L | missense | 8.239e-06 | 1 | 121376 | 0 | 0.0 | 0.923 | ||
casr_human | 471 | N-term | N => I | missense | 8.239e-06 | 1 | 121380 | 0 | 0.05 | 0.562 | ||
casr_human | 476 | N-term | Q => R | missense | 8.238e-06 | 1 | 121396 | 0 | 0.31 | 0.05 | ||
casr_human | 477 | N-term | V => A | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.78 | ||
casr_human | 482 | N-term | C => S | missense | 8.238e-06 | 1 | 121394 | 0 | 0.16 | 0.004 | ||
casr_human | 482 | N-term | C => Y | missense | 8.237e-06 | 1 | 121398 | 0 | 0.1 | 0.102 | ||
casr_human | 486 | N-term | V => L | missense | 8.237e-06 | 1 | 121400 | 0 | 0.64 | 0.013 | ||
casr_human | 488 | N-term | N => S | missense | 8.237e-06 | 1 | 121400 | 0 | 0.47 | 0.531 | PTM (N-linked Glycosylation) | |
casr_human | 491 | N-term | I => V | missense | 8.237e-06 | 1 | 121406 | 0 | 0.31 | 0.824 | ||
casr_human | 496 | N-term | L => F | missense | 8.237e-06 | 1 | 121410 | 0 | 0.7 | 0.866 | ||
casr_human | 503 | N-term | I => V | missense | 8.237e-06 | 1 | 121408 | 0 | 0.93 | 0.006 | ||
casr_human | 504 | N-term | V => M | missense | 4.118e-05 | 5 | 121408 | 0 | 0.12 | 0.004 | ||
casr_human | 506 | N-term | K => T | missense | 8.237e-06 | 1 | 121406 | 0 | 0.67 | 0.104 | ||
casr_human | 509 | N-term | G => R | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 1.0 | ||
casr_human | 510 | N-term | Y => C | missense | 8.237e-06 | 1 | 121408 | 0 | 0.11 | 0.575 | ||
casr_human | 517 | N-term | K => E | missense | 1.648e-05 | 2 | 121388 | 0 | 0.75 | 0.217 | ||
casr_human | 517 | N-term | K => N | missense | 1.648e-05 | 2 | 121384 | 0 | 0.31 | 0.009 | ||
casr_human | 518 | N-term | G => E | missense | 8.238e-06 | 1 | 121382 | 0 | 0.06 | 0.951 | ||
casr_human | 520 | N-term | R => S | missense | 8.241e-06 | 1 | 121350 | 0 | 0.05 | 0.392 | ||
casr_human | 522 | N-term | F => L | missense | 8.241e-06 | 1 | 121338 | 0 | 0.65 | 0.004 | ||
casr_human | 522 | N-term | F => L | missense | 8.242e-06 | 1 | 121324 | 0 | 0.65 | 0.004 | ||
casr_human | 525 | N-term | E => K | missense | 1.649e-05 | 2 | 121292 | 0 | 0.16 | 0.024 | ||
casr_human | 531 | N-term | S => N | missense | 8.26e-06 | 1 | 121062 | 0 | 1.0 | 0.003 | ||
casr_human | 535 | N-term | R => S | missense | 8.298e-06 | 1 | 120516 | 0 | 0.24 | 0.019 | ||
casr_human | 539 | N-term | F => L | missense | 8.237e-06 | 1 | 121410 | 0 | 0.38 | 0.013 | ||
casr_human | 541 | N-term | N => S | missense | 8.237e-06 | 1 | 121410 | 0 | 0.02 | 0.689 | ||
casr_human | 544 | N-term | R => Q | missense | 0.0007907 | 96 | 121410 | 0 | 0.06 | 0.028 | ||
casr_human | 544 | N-term | R => L | missense | 8.237e-06 | 1 | 121410 | 0 | 0.01 | 0.064 | ||
casr_human | 548 | N-term | A => T | missense | 1.647e-05 | 2 | 121412 | 0 | 0.03 | 0.01 | ||
casr_human | 555 | N-term | I => V | missense | 8.236e-06 | 1 | 121412 | 0 | 0.16 | 0.403 | ||
casr_human | 559 | N-term | P => L | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 0.876 | ||
casr_human | 560 | N-term | T => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.02 | 0.864 | ||
casr_human | 592 | N-term | N => S | missense | 0.003295 | 400 | 121400 | 8 | 0.14 | 0.136 | ||
casr_human | 594 | N-term | N => S | missense | 8.237e-06 | 1 | 121402 | 0 | 0.16 | 0.999 | ||
casr_human | 604 | N-term | E => D | missense | 8.237e-06 | 1 | 121404 | 0 | 0.01 | 0.671 | ||
casr_human | 609 | N-term | T => A | missense | 8.237e-06 | 1 | 121404 | 0 | 0.71 | 0.441 | ||
casr_human | 609 | N-term | T => M | missense | 1.647e-05 | 2 | 121402 | 0 | 0.1 | 0.959 | ||
casr_human | 615 | 1.42x42 | TM1 | A => T | missense | 1.648e-05 | 2 | 121396 | 0 | 0.39 | 0.699 | |
casr_human | 621 | 1.48x48 | TM1 | V => M | missense | 4.119e-05 | 5 | 121392 | 0 | 0.03 | 0.686 | |
casr_human | 631 | 1.58x58 | TM1 | L => V | missense | 8.24e-06 | 1 | 121358 | 0 | 0.15 | 0.596 | |
casr_human | 636 | 1.63x63 | TM1 | K => E | missense | 8.241e-06 | 1 | 121350 | 0 | 0.23 | 0.734 | |
casr_human | 638 | ICL1 | R => H | missense | 2.472e-05 | 3 | 121338 | 0 | 0.06 | 0.479 | ||
casr_human | 648 | 2.36x36 | TM2 | R => G | missense | 8.244e-06 | 1 | 121294 | 0 | 0.03 | 0.996 | |
casr_human | 648 | 2.36x36 | TM2 | R => L | missense | 3.298e-05 | 4 | 121284 | 0 | 0.04 | 0.961 | |
casr_human | 671 | ECL1 | E => V | missense | 8.249e-06 | 1 | 121226 | 0 | 0.0 | 0.677 | ||
casr_human | 676 | 3.28x28 | TM3 | T => M | missense | 8.25e-06 | 1 | 121210 | 0 | 0.0 | 0.149 | |
casr_human | 676 | 3.28x28 | TM3 | T => R | missense | 8.25e-06 | 1 | 121210 | 0 | 0.0 | 0.524 | |
casr_human | 680 | 3.32x32 | TM3 | R => C | missense | 8.25e-06 | 1 | 121210 | 0 | 0.03 | 0.999 | LB (polar (charge-assisted hydrogen bond)) |
casr_human | 680 | 3.32x32 | TM3 | R => H | missense | 1.65e-05 | 2 | 121196 | 0 | 0.0 | 0.998 | LB (polar (charge-assisted hydrogen bond)) |
casr_human | 686 | 3.38x38 | TM3 | I => V | missense | 3.299e-05 | 4 | 121240 | 0 | 0.05 | 0.034 | |
casr_human | 688 | 3.40x40 | TM3 | F => C | missense | 8.247e-06 | 1 | 121254 | 0 | 0.0 | 1.0 | |
casr_human | 695 | 3.47x47 | TM3 | I => V | missense | 8.246e-06 | 1 | 121270 | 0 | 0.35 | 0.557 | |
casr_human | 701 | 3.53x53 | TM3 | R => C | missense | 1.649e-05 | 2 | 121278 | 0 | 0.04 | 0.365 | SodiumPocket MicroSwitch |
casr_human | 702 | 3.54x54 | TM3 | V => I | missense | 8.246e-06 | 1 | 121278 | 0 | 0.04 | 0.155 | SodiumPocket MicroSwitch GP (contact) |
casr_human | 712 | ICL2 | T => N | missense | 8.251e-06 | 1 | 121192 | 0 | 0.26 | 0.988 | ||
casr_human | 713 | ICL2 | S => G | missense | 8.251e-06 | 1 | 121192 | 0 | 0.36 | 0.042 | ||
casr_human | 716 | ICL2 | R => H | missense | 1.652e-05 | 2 | 121094 | 0 | 0.14 | 0.999 | ||
casr_human | 722 | 4.30x30 | TM4 | N => K | missense | 2.479e-05 | 3 | 121030 | 0 | 0.96 | 0.843 | |
casr_human | 736 | 4.44x44 | TM4 | I => T | missense | 8.27e-06 | 1 | 120922 | 0 | 0.01 | 0.446 | |
casr_human | 737 | 4.45x45 | TM4 | V => I | missense | 1.654e-05 | 2 | 120918 | 0 | 0.34 | 0.006 | |
casr_human | 738 | 4.46x46 | TM4 | I => T | missense | 8.272e-06 | 1 | 120892 | 0 | 0.07 | 0.057 | |
casr_human | 739 | 4.47x47 | TM4 | C => Y | missense | 2.482e-05 | 3 | 120892 | 0 | 0.0 | 0.46 | |
casr_human | 744 | 4.52x52 | TM4 | Y => F | missense | 8.286e-06 | 1 | 120690 | 0 | 0.52 | 0.925 | |
casr_human | 746 | 4.54x54 | TM4 | A => T | missense | 1.659e-05 | 2 | 120524 | 0 | 0.04 | 0.955 | |
casr_human | 746 | 4.54x54 | TM4 | A => V | missense | 4.979e-05 | 6 | 120508 | 0 | 0.01 | 0.606 | |
casr_human | 749 | ECL2 | S => A | missense | 8.303e-06 | 1 | 120434 | 0 | 0.51 | 0.038 | ||
casr_human | 752 | ECL2 | R => H | missense | 2.492e-05 | 3 | 120386 | 0 | 0.0 | 0.836 | ||
casr_human | 754 | ECL2 | Q => R | missense | 8.304e-06 | 1 | 120430 | 0 | 0.33 | 0.049 | ||
casr_human | 755 | ECL2 | E => D | missense | 2.491e-05 | 3 | 120434 | 0 | 0.33 | 0.046 | ||
casr_human | 764 | ECL2 | T => M | missense | 8.295e-06 | 1 | 120550 | 0 | 0.0 | 0.991 | ||
casr_human | 766 | 45.51x51 | ECL2 | H => Y | missense | 8.294e-06 | 1 | 120568 | 0 | 0.11 | 0.659 | |
casr_human | 768 | ECL2 | G => V | missense | 4.144e-05 | 5 | 120648 | 0 | 0.0 | 0.961 | ||
casr_human | 772 | 5.39x39 | TM5 | A => T | missense | 8.285e-06 | 1 | 120698 | 0 | 0.01 | 0.995 | |
casr_human | 779 | 5.46x46 | TM5 | Y => H | missense | 8.28e-06 | 1 | 120770 | 0 | 0.0 | 1.0 | |
casr_human | 780 | 5.47x47 | TM5 | T => I | missense | 8.277e-06 | 1 | 120812 | 0 | 1.0 | 0.974 | SodiumPocket MicroSwitch LB (Van der Waals) |
casr_human | 786 | 5.53x53 | TM5 | I => V | missense | 2.48e-05 | 3 | 120964 | 0 | 0.64 | 0.005 | |
casr_human | 802 | 6.34x34 | TM6 | N => S | missense | 1.649e-05 | 2 | 121312 | 0 | 0.0 | 0.897 | GP (contact) |
casr_human | 804 | 6.36x36 | TM6 | A => S | missense | 1.648e-05 | 2 | 121324 | 0 | 0.0 | 0.899 | SodiumPocket MicroSwitch |
casr_human | 813 | 6.45x45 | TM6 | I => V | missense | 2.472e-05 | 3 | 121368 | 0 | 0.09 | 0.487 | |
casr_human | 819 | 6.51x51 | TM6 | I => M | missense | 8.238e-06 | 1 | 121384 | 0 | 0.02 | 0.973 | |
casr_human | 825 | 6.57x57 | TM6 | Y => C | missense | 8.237e-06 | 1 | 121398 | 0 | 0.0 | 0.998 | LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
casr_human | 850 | 7.45x46 | TM7 | A => E | missense | 8.24e-06 | 1 | 121356 | 0 | 0.06 | 0.962 | |
casr_human | 851 | 7.46x47 | TM7 | C => S | missense | 1.648e-05 | 2 | 121350 | 0 | 0.03 | 1.0 | |
casr_human | 857 | 7.52x52 | TM7 | I => T | missense | 8.244e-06 | 1 | 121302 | 0 | 0.0 | 0.049 | |
casr_human | 858 | 7.53x53 | TM7 | Y => D | missense | 8.244e-06 | 1 | 121304 | 0 | 0.0 | 1.0 | |
casr_human | 862 | 7.57x57 | TM7 | F => S | missense | 0.0001154 | 14 | 121276 | 0 | 0.0 | 0.33 | |
casr_human | 880 | C-term | A => S | missense | 1.654e-05 | 2 | 120944 | 0 | 0.11 | 0.47 | ||
casr_human | 890 | C-term | R => C | missense | 8.302e-06 | 1 | 120460 | 0 | nan | 0.708 | ||
casr_human | 890 | C-term | R => H | missense | 8.3e-06 | 1 | 120476 | 0 | nan | 0.708 | ||
casr_human | 891 | C-term | R => H | missense | 1.66e-05 | 2 | 120460 | 0 | nan | 0.023 | ||
casr_human | 894 | C-term | V => F | missense | 2.49e-05 | 3 | 120502 | 0 | nan | 0.118 | ||
casr_human | 896 | C-term | R => G | missense | 8.3e-06 | 1 | 120480 | 0 | nan | 0.994 | ||
casr_human | 896 | C-term | R => C | missense | 8.3e-06 | 1 | 120480 | 0 | nan | 0.997 | ||
casr_human | 896 | C-term | R => L | missense | 8.299e-06 | 1 | 120494 | 0 | nan | 0.994 | ||
casr_human | 898 | C-term | R => Q | missense | 3.32e-05 | 4 | 120496 | 0 | nan | 0.347 | ||
casr_human | 899 | C-term | S => P | missense | 8.296e-06 | 1 | 120536 | 0 | nan | 0.265 | PTM (Phosphorylation) | |
casr_human | 904 | C-term | G => A | missense | 8.294e-06 | 1 | 120568 | 0 | nan | 0.998 | ||
casr_human | 907 | C-term | G => A | missense | 8.292e-06 | 1 | 120596 | 0 | nan | 0.038 | ||
casr_human | 908 | C-term | S => Y | missense | 8.291e-06 | 1 | 120606 | 0 | nan | 0.679 | ||
casr_human | 913 | C-term | S => F | missense | 1.657e-05 | 2 | 120674 | 0 | nan | 0.456 | ||
casr_human | 920 | C-term | S => N | missense | 8.276e-06 | 1 | 120832 | 0 | nan | 0.085 | ||
casr_human | 920 | C-term | S => R | missense | 1.656e-05 | 2 | 120806 | 0 | nan | 0.209 | ||
casr_human | 921 | C-term | E => K | missense | 1.655e-05 | 2 | 120842 | 0 | nan | 0.385 | ||
casr_human | 922 | C-term | D => H | missense | 8.275e-06 | 1 | 120844 | 0 | nan | 0.914 | ||
casr_human | 923 | C-term | P => A | missense | 2.482e-05 | 3 | 120860 | 0 | nan | 0.003 | ||
casr_human | 924 | C-term | F => L | missense | 8.273e-06 | 1 | 120868 | 0 | nan | 0.015 | ||
casr_human | 926 | C-term | Q => R | missense | 0.0001324 | 16 | 120880 | 0 | nan | 0.002 | ||
casr_human | 931 | C-term | K => Q | missense | 8.278e-06 | 1 | 120796 | 0 | nan | 0.002 | ||
casr_human | 937 | C-term | A => G | missense | 8.266e-06 | 1 | 120984 | 0 | nan | 0.01 | ||
casr_human | 942 | C-term | E => K | missense | 0.0008266 | 100 | 120980 | 2 | nan | 0.014 | ||
casr_human | 947 | C-term | P => S | missense | 8.257e-06 | 1 | 121112 | 0 | nan | 0.057 | ||
casr_human | 947 | C-term | P => L | missense | 8.256e-06 | 1 | 121122 | 0 | nan | 0.057 | ||
casr_human | 948 | C-term | L => P | missense | 8.256e-06 | 1 | 121130 | 0 | nan | 0.001 | ||
casr_human | 950 | C-term | L => P | missense | 3.302e-05 | 4 | 121144 | 0 | nan | 0.0 | ||
casr_human | 953 | C-term | Q => E | missense | 2.476e-05 | 3 | 121178 | 0 | 1.0 | 0.002 | ||
casr_human | 957 | C-term | Q => R | missense | 3.299e-05 | 4 | 121246 | 0 | nan | 0.041 | ||
casr_human | 962 | C-term | C => R | missense | 8.245e-06 | 1 | 121286 | 0 | nan | 0.316 | ||
casr_human | 967 | C-term | I => V | missense | 8.243e-06 | 1 | 121314 | 0 | nan | 0.051 | ||
casr_human | 972 | C-term | T => M | missense | 4.121e-05 | 5 | 121326 | 0 | nan | 0.124 | ||
casr_human | 974 | C-term | T => I | missense | 2.473e-05 | 3 | 121332 | 0 | nan | 0.996 | ||
casr_human | 985 | C-term | N => T | missense | 8.242e-06 | 1 | 121330 | 0 | nan | 0.033 | ||
casr_human | 986 | C-term | A => S | missense | 0.1269 | 15391 | 121254 | 1237 | nan | 0.012 | ||
casr_human | 988 | C-term | A => V | missense | 1.649e-05 | 2 | 121310 | 0 | nan | 0.003 | ||
casr_human | 990 | C-term | R => G | missense | 0.1451 | 17589 | 121184 | 2401 | nan | 0.116 | ||
casr_human | 993 | C-term | T => M | missense | 1.649e-05 | 2 | 121284 | 0 | nan | 0.002 | ||
casr_human | 1001 | C-term | Q => K | missense | 8.248e-06 | 1 | 121244 | 0 | nan | 0.012 | ||
casr_human | 1004 | C-term | S => R | missense | 8.246e-06 | 1 | 121270 | 0 | nan | 0.038 | ||
casr_human | 1005 | C-term | D => N | missense | 3.299e-05 | 4 | 121254 | 0 | nan | 0.141 | ||
casr_human | 1005 | C-term | D => Y | missense | 8.247e-06 | 1 | 121254 | 0 | nan | 0.735 | ||
casr_human | 1006 | C-term | T => M | missense | 8.248e-06 | 1 | 121246 | 0 | nan | 0.195 | ||
casr_human | 1009 | C-term | R => Q | missense | 8.252e-06 | 1 | 121188 | 0 | nan | 0.077 | ||
casr_human | 1009 | C-term | R => L | missense | 8.252e-06 | 1 | 121188 | 0 | nan | 0.127 | ||
casr_human | 1010 | C-term | H => Y | missense | 8.249e-06 | 1 | 121232 | 0 | nan | 0.153 | ||
casr_human | 1010 | C-term | H => Q | missense | 8.253e-06 | 1 | 121168 | 0 | nan | 0.096 | ||
casr_human | 1012 | C-term | P => T | missense | 8.241e-06 | 1 | 121346 | 0 | nan | 0.0 | ||
casr_human | 1013 | C-term | L => S | missense | 8.241e-06 | 1 | 121344 | 0 | nan | 0.997 | ||
casr_human | 1014 | C-term | L => I | missense | 1.648e-05 | 2 | 121340 | 0 | nan | 0.002 | ||
casr_human | 1015 | C-term | P => L | missense | 8.241e-06 | 1 | 121340 | 0 | nan | 0.579 | ||
casr_human | 1016 | C-term | L => P | missense | 8.24e-06 | 1 | 121354 | 0 | nan | 0.999 | ||
casr_human | 1017 | C-term | Q => R | missense | 8.241e-06 | 1 | 121350 | 0 | nan | 0.008 | ||
casr_human | 1021 | C-term | T => K | missense | 8.242e-06 | 1 | 121328 | 0 | nan | 0.025 | ||
casr_human | 1027 | C-term | V => I | missense | 8.246e-06 | 1 | 121266 | 0 | nan | 0.001 | ||
casr_human | 1027 | C-term | V => A | missense | 8.247e-06 | 1 | 121256 | 0 | nan | 0.0 | ||
casr_human | 1029 | C-term | E => D | missense | 8.251e-06 | 1 | 121204 | 0 | nan | 0.002 | ||
casr_human | 1031 | C-term | G => S | missense | 0.0002228 | 27 | 121160 | 1 | nan | 0.002 | ||
casr_human | 1035 | C-term | P => S | missense | 1.652e-05 | 2 | 121062 | 0 | nan | 0.0 | ||
casr_human | 1038 | C-term | G => R | missense | 8.262e-06 | 1 | 121032 | 0 | nan | 0.68 | ||
casr_human | 1041 | C-term | R => W | missense | 2.48e-05 | 3 | 120984 | 0 | nan | 0.292 | ||
casr_human | 1043 | C-term | E => V | missense | 8.268e-06 | 1 | 120950 | 0 | nan | 0.226 | ||
casr_human | 1045 | C-term | E => D | missense | 8.272e-06 | 1 | 120896 | 0 | nan | 0.022 | ||
casr_human | 1048 | C-term | E => K | missense | 8.277e-06 | 1 | 120818 | 0 | nan | 0.031 | ||
casr_human | 1051 | C-term | S => P | missense | 8.286e-06 | 1 | 120692 | 0 | nan | 0.001 | ||
casr_human | 1063 | C-term | V => I | missense | 8.343e-06 | 1 | 119868 | 0 | nan | 0.007 | ||
casr_human | 1065 | C-term | S => G | missense | 6.683e-05 | 8 | 119708 | 0 | nan | 0.08 | ||
casr_human | 1066 | C-term | G => D | missense | 8.366e-06 | 1 | 119526 | 0 | nan | 0.998 | ||
casr_human | 1074 | C-term | N => D | missense | 8.464e-06 | 1 | 118150 | 0 | nan | 0.103 | ||
casr_human | 1075 | C-term | V => L | missense | 8.48e-06 | 1 | 117926 | 0 | nan | 0.002 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue